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Type of Document Master's Thesis Author Kling, Dale Lee Author's Email Address dkling@nd.edu URN etd-04112006-183339 Title Conformationally Constrained Aminoglycosides: Ribosomal Binding Probes and Potential Antibiotics Degree Master of Science Department Chemistry and Biochemistry Advisory Committee
Advisor Name Title Shahriar Mobashery Committee Chair Dr. Bradley Smith Committee Member Dr. Marvin Miller Committee Member Dr. Paul Helquist Committee Member Keywords
- antibiotics
- aminoglycosides
Date of Defense 2006-03-30 Availability unrestricted Abstract Conformational constraints were placed on derivatives of neamine, a subclass of aminoglycosides, via an N3-N6' linkage in order to investigate the relevance of conformational states in binding the bacterial ribosome. Additionally, an understanding of how this new class of compounds behaves in the presence of aminoglycoside modifying enzymes was sought.Files
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