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Type of Document Dissertation Author Hogan, James Robert Author's Email Address jhogan1@nd.edu URN etd-07172006-105357 Title ANALYSIS OF THE GENOMIC ARCHITECTURE OF ANOPHELES GAMBIAE Degree Doctor of Philosophy Department Biological Sciences Advisory Committee
Advisor Name Title Dr. Frank Collins Committee Chair Dr Jeanne Romero-Severson Committee Member Dr. Dave Severson Committee Member Dr. Joseph OTousa Committee Member Keywords
- synteny
- transposable elements
- Anopheles gambiae
- microsatellites
Date of Defense 2006-06-27 Availability unrestricted Abstract Malaria still kills over one million people a year, mostly children in sub-Saharan Africa. Anopheles gambiae is the main malaria vector in sub-Saharan Africa. The publication of the An. gambiae genome in 2002 opened up a vast array of information that potentially can be used in controlling this deadly mosquito. However, this vast assortment of genomic data also opened up the challenge of being able to parse through this data to identify useful information,To help organize this data into manageable quantities this thesis focuses on three main genomic structures in An. gambiae: 1) microsatellites, 2) syntenic relationships between the genome of An. gambiae and D. melanogaster, and 3)Tc1-mariner superfamily transposable element distribution
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